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Cellophane maculopathy

Caused by an epiretinal membrane, clinically, it appears as a sheen abnormal foveal reflex which features epiretinal membrane, due to inflammatory mediators and proliferation of glial cells secondary to a partial separation of posterior cortical vitreous.

Fundus image shows cellophane maculopathy
Fundus image shows cellophane maculopathy


OCT features a hyperreflective band covering the inner retinal layers, causing minimal disturbance of inner retinal tissues.

OCT cross-section shows epiretinal membrane
OCT cross-section shows epiretinal membrane 


Cellophane maculopathy itself in individuals with good visual acuity may not need any interventions, but it is warranted to do a detailed peripheral retinal exam to rule out retinal tear or hole

However, an epiretinal membrane may proliferate further and cause additional tangential traction. Thus, it may induce macular pucker or lamellar/pseudo hole and increase disturbance of inner retinal tissues, macular thickness, and reduction of vision.

These patients may require pars plana vitrectomy to remove the epiretinal membrane and some cases, ILM peeling.

Drop a comment below on how would you approach a case of cellophane maculopathy in your clinical practice ??


Please check Clinical guidelines for epiretinal membrane and vitreomacular traction

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